Cor a 14, the allergenic 2S albumin from hazelnut, is highly thermostable and resistant to gastrointestinal digestion
نویسندگان
چکیده
منابع مشابه
Cor a 14, the allergenic 2S albumin from hazelnut, is highly thermostable and resistant to gastrointestinal digestion
SCOPE Allergens from nuts frequently induce severe allergic reactions in sensitive individuals. The aim of this study was to elucidate the physicochemical characteristics of natural Cor a 14, the 2S albumin from hazelnut. METHODS AND RESULTS Cor a 14 was purified from raw hazelnuts using a combination of precipitation and chromatographic techniques. The protein was analyzed using gel electrop...
متن کاملPurification and characterisation of natural Cor a 14, the 2S albumin from hazelnut, and its isoforms
Background and aim Allergens from nuts are known to often induce severe allergic reactions in sensitive individuals. Nuts are a nutrient dense food and a good source of unsaturated fatty acids and other lipids. The allergenic properties of hazelnut allergens could be altered by binding to or being in close proximity to these lipids. The aim of this study was to purify and characterize natural C...
متن کاملSensitisation to Cor a 14 and Cor a 9 is a risk marker for severe hazelnut allergy in children
Background Hazelnut-allergic children express variable clinical phenotypes. Tests for the diagnosis of hazelnut allergy are usually conducted on children presenting clinical symptoms following hazelnut ingestion, but also as screening tests after the discovery of a food allergy, mainly to tree nut or peanut. It is important to determine if molecular allergens could be markers of severity in haz...
متن کاملSensitization to cor a 9 and cor a 14 is highly specific for a hazelnut allergy with objective symptoms in dutch children and adults.
BACKGROUND Component-resolved diagnosis has been shown to improve the diagnosis of food allergy. OBJECTIVE We sought to evaluate whether component-resolved diagnosis might help to identify patients at risk of objective allergic reactions to hazelnut. METHOD A total of 161 hazelnut-sensitized patients were included: 40 children and 15 adults with objective symptoms on double-blind, placebo-c...
متن کاملSensitization to Cor a 9 and Cor a 14 is highly specific for a severe hazelnut allergy in Dutch children and adults
Results IgE to hazelnut extract was significantly higher in children with severe than with no or mild symptoms. Sensitization to rCor a 1.04 was common among both children and adults, while sensitization to rCor a 8 was rare. In 13% of children and 49% of adults with a severe hazelnut allergy, only sensitization to rCor a 1.04 was observed and not to other water-soluble allergens. Sensitization...
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ژورنال
عنوان ژورنال: Molecular Nutrition & Food Research
سال: 2015
ISSN: 1613-4125,1613-4133
DOI: 10.1002/mnfr.201500071